AMELOBLASTIC FIBRO SARCOMA PDF

This article has been cited by other articles in PMC. Abstract Ameloblastic fibrosarcoma AFS is a rare malignant mixed odontogenic tumor which is usually considered as the malignant counterpart of ameloblastic fibroma. Only mesenchymal component represents sarcomatous alterations and ameloblast-like epithelial nest remains bland in AFS. Here, we report a case of AFS in a year-old man in the maxilla, which was regarded as an uncommon location for this tumor. After 2 years follow up, no evidence of recurrence was noted.

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The differential diagnosis includes other odontogenic sarcomas, ameloblastic carcinosarcoma and spindle cell carcinoma. Ameloblastic fibrosarcoma of the upper jaw: Report of a rare case with long-term follow-up Page views in Case Report A year-old female presented with a 2-month history of an asymptomatic swelling in her left mandible.

Amellblastic fibrosarcoma AFS is a rare malignant odontogenic tumor. This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.

The surgeon decided to ask for a second opinion and sent the documents to our center for consultation. Support Center Support Center. Radiographically, the tumor usually shows a destructive radiolucent pattern with ill-defined borders suggestive of malignancy.

Assessment of growth potential by MIB-1 immunohistochemistry in ameloblastic fibroma and related lesions of the jaws compared with ameloblastic fibrosarcoma. PCNA wmeloblastic strongly positive in both components, while p53 was strongly positive only in the mesenchymal component. Images hosted on fibto servers: It mainly presents as a painful maxillary or mandibular swelling. The usual clinical presentation consists of a patient who complains of a painful but occasionally painless facial mass with accompanying paresthesia or dysesthesia.

Maryam Khalili 1 and Pouyan Amini Shakib 2. Ameloblastic fibrosarcoma AFS is a rare malignant mixed odontogenic tumor which is usually considered as the malignant counterpart of ameloblastic fibroma. A diagnosis of AFS was rendered. However, adjuvant radiotherapy was also performed in order to ensure a better outcome.

Biphasic with benign epithelium and malignant stroma: Patients often present with swelling and pain Occasionally painless facial mass with accompanying paresthesia. The mean age at the time of diagnosis of AFS for 62 cases reviewed by Bregni et al. Restricted molecular abnormalities of certain genes to the malignant transformation. Histopathological examination revealed a biphasic tumor composed of inconspicuous islands of benign odontogenic epithelium and an abundant malignant mesenchymal component with marked cellularity, nuclear pleomorphism, hyperchromatism, and moderate mitotic figures Figure 2.

Oral and Maxillofacial Pathology, 4th Edition, Radiographic examination showed an extensive ill-defined unilocular radiolucent lesion around an impacted mandibular left first molar. The mesenchymal component consists of plump and spindle stromal cells which swrcoma mild to moderate cytologic atypia and numerous mitotic figures [ 11 ]. It is critical to differentiate AFS, especially low-grade variant, from ameloblastic fibroma, and recently, several immunohistochemical studies with Ki67, Bcl-2, PCNA, c-KIT, and P53 have been performed, suggesting that proliferating markers in association to histopathologic features could be useful for identifying the malignant tumor.

An odontogenic lesion was the clinical impression and an incisional biopsy was performed. Paresthesia is also observed. Conflict of Interests The authors have no conflict of interests to declare. AF is the main differential diagnosis of AFS. We report the case of a year-old female with ame,oblastic 2-month history of an asymptomatic swelling in her left mandible. Panoramic radiograph showing area of mandibular resection with no evidence of recurrence sarcomw year after surgery.

Immunoexpression of Ki67, proliferative cell nuclear antigen, and Bcl-2 proteins in a case of ameloblastic fibrosarcoma. The posterior mandible is the most commonly affected site [ 8 ]. Case report and literature review. Malignant amelbolastic tumors are classified as odontogenic carcinomas and odontogenic sarcomas [ 1 ]. Recently, some authors have suggested a ameloblastif of biomarkers associated with cell proliferation Ki67, PCNA, and c-KIT and apoptosis Bcl2 to overcome difficulties in the diagnosis of low-grade tumors and evaluate the growth potential in the mesenchymal component without considering clinical and radiographic findings.

Amelobllastic overgrowth in recurrent ameloblastic fibrosarcoma. Adjuvant chemotherapy has also been used with moderate success [ 17 ], although no specific chemotherapy protocols have been established yet. Journal List Case Rep Pathol v. To the best of our knowledge, less than documented cases have been reported in the English language literature [ 6 ].

Malignant transformation of ameloblastic fibroma to ameloblastic fibrosarcoma: Microscopically, the bland epithelial component of AFS is similar to that seen in ameloblastic fibroma, although it is frequently less prominent. He performed an incisional biopsy and sent it to a general pathology service for histopathologic examination. TOP Related Articles.

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Ameloblastic fibrosarcoma of the upper jaw: Report of a rare case with long-term follow-up

China Correspondence to: Mr. China, E-mail: nc. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. Abstract Ameloblastic fibro-odontosarcoma AFOS is an extremely rare subtype of odontogenic sarcoma, with no more than 19 cases reported in the English literature to date. AFOS is a biphasic neoplasm, with deposits of dentin and enamel matrix.

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AMELOBLASTIC FIBRO SARCOMA PDF

Summary 1. Introduction Ameloblastic fibrosarcoma AFS is a malignant odontogenic tumour characteristically composed of a benign epithelium and a malignant mesenchymal component. They are classified as odontogenic carcinomas and odontogenic sarcomas. Case Report We report a case of 17 year old female who presented with a painful left mandibular swelling. Biopsy from the lesion was inconclusive. Patient underwent a left extended hemimandibulectomy with modified radical neck dissection.

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Tojam Ameloblastic fibrosarcoma of the upper jaw: Report of a rare case with long-term follow-up Ameloblastic fibrosarcoma of the jaw: Journal of Cranio-Maxillo-Facial Surgery. Annals of Diagnostic Pathology. Rare, More common in males 1. The mesenchymal component consists of plump and spindle stromal cells which show mild to moderate cytologic atypia and numerous mitotic figures [ 11 ].

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