BETA LAKTAM ANTIBIYOTIKLER PDF

Allerdings sind viele Bakterien in der Lage, ein spezielles Enzym zu produzieren, das die Struktur des Rings bricht, wodurch das Antibiotikum seiner Hauptwaffe entzogen wird. Deshalb ist die Verwendung von Medikamenten, die keinen Schutz gegen Beta-Lactamasen in der Behandlung haben, unwirksam. Mikroorganismen sind in der Lage, sich schnell an eine Vielzahl von komplexen Bedingungen der Existenz anzupassen, die Geburt von Generationen von Antibiotika-resistente Bakterien. Antistaphylokokken "Oxacillin".

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OXA tipi beta-laktamazlar da, P. ABSTRACT Pseudomonas aeruginosa is a well-known cause of severe and potentially life-threatening infections including bacteremia, skin and wound infections, pulmonary disease, especially among indivuals with cycstic fibrosis, nosocomial urinary tract infections, endocarditis and meningitis. The mechanism of resistance to broad-spectrum beta-lactams in P. OXA beta-lactamases have increasingly been reported in clinical strains of P.

This study was aimed to investigate the antibiotic susceptibility of various P. In this study, a total of P. According to Clinical and Laboratory Standards Institute CLSI recommendations, susceptibilities of isolates to various antibiotics were investigated by disk diffusion and agar dilution method, and beta-lactamase enzymes were detected by isoelectric focusing IEF method. Seven of the isolates were found to be ESBL positive by double-disk synergy method.

Phenotypical investigation of metallo-beta-lactamase enzyme in these strains by MBL E-test method did not reveal a positive result. PSE gene was not found in any of the strains. Antibiotic resistance mechanisms in P. Determination of the resistance mechanisms and antibiotic susceptibility rates in P.

Key words: P. Kalite kontrol olarak P. Sonikatlar J Antimicrob Chemother ; 50 1 :

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